Table of Contents
1 Enzyme Replacement Therapy Market Overview1
1.1 Product Overview and Scope of Enzyme Replacement Therapy1
1.2 Enzyme Replacement Therapy Segment by Types (Product Category)2
1.2.1 Global Enzyme Replacement Therapy Sales by Types2
1.2.2 Global Enzyme Replacement Therapy Revenue Market Share by Types in 20203
1.2.3 Injectable Agents4
1.2.4 Oral Agents4
1.3 Global Enzyme Replacement Therapy Segment by Applications5
1.3.1 Global Enzyme Replacement Therapy Comparison by Applications5
1.3.2 Gaucher Disease7
1.3.3 Fabry Disease8
1.3.4 MPS Disease8
1.3.5 Gastrointestinal Disease9
1.4 Global Enzyme Replacement Therapy Market by Regions ( 2016 - 2027)9
1.4.1 Global Enzyme Replacement Therapy Market Size Comparison by Regions ( 2016 - 2027)9
1.4.2 North America Enzyme Replacement Therapy Status and Prospect ( 2016 - 2027)10
1.4.3 Europe Enzyme Replacement Therapy Status and Prospect ( 2016 - 2027)11
1.4.4 Asia - Pacific Enzyme Replacement Therapy Status and Prospect ( 2016 - 2027)12
1.4.5 South America Enzyme Replacement Therapy Status and Prospect ( 2016 - 2027)13
1.4.6 Middle East and Africa Enzyme Replacement Therapy Status and Prospect ( 2016 - 2027)14
1.5 Global Enzyme Replacement Therapy Market Size ( 2016 - 2027)15
1.5.1 Global Enzyme Replacement Therapy Revenue Status and Outlook ( 2016 - 2027)15
1.5.2 Global Enzyme Replacement Therapy Sales Status and Outlook ( 2016 - 2027)16
2 Global Enzyme Replacement Therapy Market Competition by Manufacturers17
2.1 Global Enzyme Replacement Therapy Sales and Share by Manufacturers ( 2020 - 2021)17
2.2 Global Enzyme Replacement Therapy Revenue and Share by Manufacturers ( 2020 - 2021)19
2.3 Global Enzyme Replacement Therapy Average Price by Manufacturers ( 2020 - 2021)22
2.4 Manufacturers Enzyme Replacement Therapy Headquarters, Established Date and Product Type23
2.5 Enzyme Replacement Therapy Market Competitive Situation and Trends25
2.5.1 Enzyme Replacement Therapy Market Concentration Rate25
2.5.2 Enzyme Replacement Therapy Market Share of Top 3 and Top 5 Manufacturers26
2.5.3 Mergers & Acquisitions, Expansion27
3 Global Enzyme Replacement Therapy Sales by Regions ( 2016 - 2021)30
3.1 Global Enzyme Replacement Therapy Sales and Market Share by Regions ( 2016 - 2021)30
3.2 Global Enzyme Replacement Therapy Revenue and Market Share by Regions ( 2016 - 2021)32
3.3 Global Enzyme Replacement Therapy Sales, Revenue, Price and Gross Margin ( 2016 - 2021)35
3.4 North America Enzyme Replacement Therapy Sales ( 2016 - 2021)36
3.4.1 North America Enzyme Replacement Therapy Sales and Growth Rate ( 2016 - 2021)36
3.4.2 North America Enzyme Replacement Therapy Sales, Revenue, Price and Gross Margin ( 2016 - 2021)36
3.5 Europe Enzyme Replacement Therapy Sales ( 2016 - 2021)37
3.5.1 Europe Enzyme Replacement Therapy Sales and Growth Rate ( 2016 - 2021)37
3.5.2 Europe Enzyme Replacement Therapy Sales, Revenue, Price and Gross Margin ( 2016 - 2021)38
3.6 Asia - Pacific Enzyme Replacement Therapy Sales ( 2016 - 2021)39
3.6.1 Asia - Pacific Enzyme Replacement Therapy Sales and Growth Rate ( 2016 - 2021)39
3.6.2 Asia - Pacific Enzyme Replacement Therapy Sales, Revenue, Price and Gross Margin ( 2016 - 2021)39
3.7 South America Enzyme Replacement Therapy Sales ( 2016 - 2021)40
3.7.1 South America Enzyme Replacement Therapy Sales and Growth Rate ( 2016 - 2021)40
3.7.2 South America Enzyme Replacement Therapy Sales, Revenue, Price and Gross Margin ( 2016 - 2021)41
3.8 Middle East & Africa Enzyme Replacement Therapy Sales ( 2016 - 2021)42
3.8.1 Middle East & Africa Enzyme Replacement Therapy Sales and Growth Rate ( 2016 - 2021)42
3.8.2 Middle East & Africa Enzyme Replacement Therapy Sales, Revenue, Price and Gross Margin ( 2016 - 2021)42
4 Global Enzyme Replacement Therapy Sales, Revenue (Value), Price Trend by Types44
4.1 Global Enzyme Replacement Therapy Sales and Market Share by Types ( 2016 - 2021)44
4.2 Global Enzyme Replacement Therapy Revenue and Market Share by Types ( 2016 - 2021)46
4.3 Global Enzyme Replacement Therapy Price by Types ( 2016 - 2021)47
4.4 Global Enzyme Replacement Therapy Sales Growth Rate by Types ( 2016 - 2021)48
5 Global Enzyme Replacement Therapy Market Analysis by Applications49
5.1 Global Enzyme Replacement Therapy Sales and Market Share by Applications ( 2016 - 2021)49
5.2 Global Enzyme Replacement Therapy Sales Growth Rate by Applications ( 2016 - 2021)52
6 Analysis of Enzyme Replacement Therapy Industry Key Manufacturers53
6.1 Sanofi53
6.1.1 Company Profile53
6.1.2 Product Information54
6.1.3 Sales, Price, Cost, Gross Profit, and Revenue55
6.2 Shire55
6.2.1 Company Profile55
6.2.2 Product Information56
6.2.3 Sales, Price, Cost, Gross Profit, and Revenue57
6.3 BioMarin58
6.3.1 Company Profile58
6.3.2 Product Information59
6.3.3 Sales, Price, Cost, Gross Profit, and Revenue60
6.4 AbbVie61
6.4.1 Company Profile61
6.4.2 Product Information62
6.4.3 Sales, Price, Cost, Gross Profit, and Revenue63
6.5 Alexion63
6.5.1 Company Profile63
6.5.2 Product Information64
6.5.3 Sales, Price, Cost, Gross Profit, and Revenue65
6.6 Allergan65
6.6.1 Company Profile65
6.6.2 Product Information66
6.6.3 Sales, Price, Cost, Gross Profit, and Revenue67
6.7 Horizon Pharma67
6.7.1 Company Profile67
6.7.2 Product Information68
6.7.3 Sales, Price, Cost, Gross Profit, and Revenue69
6.8 Johnson & Johnson69
6.8.1 Company Profile69
6.8.2 Product Information71
6.8.3 Sales, Price, Cost, Gross Profit, and Revenue72
6.9 Actelion72
6.9.1 Company Profile72
6.9.2 Product Information73
6.9.3 Sales, Price, Cost, Gross Profit, and Revenue73
6.10 Recordati Rare Diseases74
6.10.1 Company Profile74
6.10.2 Product Information75
6.10.3 Sales, Price, Cost, Gross Profit, and Revenue76
6.11 Pfizer76
6.11.1 Company Profile76
6.11.2 Product Information77
6.11.3 Sales, Price, Cost, Gross Profit, and Revenue78
6.12 Digestive Care78
6.12.1 Company Profile78
6.12.2 Product Information79
6.12.3 Sales, Price, Cost, Gross Profit, and Revenue79
6.13 Leadiant Biosciences80
6.13.1 Company Profile80
6.13.2 Product Information81
6.13.3 Sales, Price, Cost, Gross Profit, and Revenue82
7 Enzyme Replacement Therapy Manufacturing Cost Analysis83
7.1 Enzyme Replacement Therapy Drugs R&D Cost Analysis83
7.1.1 Clinical Phase Costs84
7.1.2 Capitalized Costs85
7.2 Proportion of Manufacturing Cost Structure86
7.2.1 Raw Materials86
7.2.2 Labor Cost87
7.2.2.1 USA Labor Cost Analysis87
7.2.2.2 Europe Labor Costs Analysis89
7.2.2.3 Asia Labor Costs Analysis91
7.2.3 Other Costs Analysis93
7.2.3.1 USA Cost of Electricity Analysis94
7.2.3.2 USA Water Cost Analysis94
7.2.3.3 Europe Cost of Electricity Analysis95
7.2.3.4 Europe Water Cost Analysis96
7.2.3.5 China Cost of Electricity Analysis96
7.2.3.6 China Water Cost Analysis97
7.3 Manufacturing Process Analysis of Enzyme Replacement Therapy98
8 Industrial Chain, Sourcing Strategy and Downstream Buyers99
8.1 Enzyme Replacement Therapy Industrial Chain Analysis99
8.2 Upstream Raw Materials Sourcing100
8.3 Downstream Buyers100
9 Marketing Strategy Analysis, Distributors/Traders103
9.1 Marketing Channel103
9.1.1 Direct Marketing105
9.1.2 Indirect Marketing106
9.1.3 Marketing Channel Development Trend107
9.2 Market Positioning108
9.2.1 Pricing Strategy108
9.2.2 Brand Strategy109
9.2.2.1 Introducing pharmaceutical branding strategies109
9.2.2.2 Building pharmaceutical brands110
9.2.2.3 Communicating pharmaceutical brands110
9.2.2.4 Alternative brand models111
9.2.2.5 The future of pharmaceutical branding112
9.3 Distributors/Traders List112
10 Market Effect Factors Analysis114
10.1 New Drug Development114
10.1.1 Avrobio Raises $60M for Fabry Disease Gene Therapy, Rest of Pipeline114
10.1.2 RVT - 801 (RHAC)116
10.1.3 AzurRx BioPharma116
10.2 Consumer Needs/Customer Preference Change117
10.3 Economic/Political Environmental Change117
11 Global Enzyme Replacement Therapy Market Forecast126
11.1 Global Enzyme Replacement Therapy Sales, Revenue Forecast126
11.1.1 Global Enzyme Replacement Therapy Sales and Growth Rate Forecast (2019 - 2027)126
11.1.2 Global Enzyme Replacement Therapy Revenue and Growth Rate Forecast (2019 - 2027)127
11.2 Global Enzyme Replacement Therapy Sales and Revenue Forecast by Regions (2019 - 2027)127
11.2.1 North America Enzyme Replacement Therapy Sales and Revenue Forecast (2019 - 2027)129
11.2.2 Europe Enzyme Replacement Therapy Sales and Revenue Forecast (2019 - 2027)131
11.2.3 Asia - Pacific Enzyme Replacement Therapy Sales and Revenue Forecast (2019 - 2027)133
11.2.4 South America Enzyme Replacement Therapy Sales and Revenue Forecast (2019 - 2027)135
11.2.5 Middle East and Africa Enzyme Replacement Therapy Sales and Revenue Forecast (2019 - 2027)137
11.3 Global Enzyme Replacement Therapy Sales, Revenue, Price Forecast by Type (2019 - 2027)138
11.4 Global Enzyme Replacement Therapy Revenue Forecast by Application (2019 - 2027)140
12 Research Findings and Conclusion142
13 Methodology and Data Source143
13.1 Methodology/Research Approach143
13.1.1 Research Programs/Design143
13.1.2 Market Size Estimation144
13.1.3 Market Breakdown and Data Triangulation145
13.2 Data Source146
13.2.1 Secondary Sources146
13.2.2 Primary Sources147
13.3 Disclaimer148
13.4 Author List149
List of Tables and Figures
Figure Product Picture of Enzyme Replacement Therapy1
Table Global Enzyme Replacement Therapy Comparison by Types2
Table Global Enzyme Replacement Therapy Revenue (M USD) and Growth Rate Comparison by Types ( 2016 - 2027)2
Figure Global Enzyme Replacement Therapy Revenue Market Share by Types in 20203
Figure Product Picture of Injectable Agents4
Figure Product Picture of Oral Agents4
Table Global Enzyme Replacement Therapy Comparison by Applications5
Table Global Enzyme Replacement Therapy Revenue (M USD) and Growth Rate Comparison by Applications ( 2016 - 2027)6
Figure Global Enzyme Replacement Therapy Revenue Market Share by Applications in 20207
Figure Gaucher Disease Examples7
Figure Fabry Disease Examples8
Figure MPS Disease Examples8
Figure Gastrointestinal Disease Examples9
Table Global Enzyme Replacement Therapy Market Size (M USD) Comparison by Regions ( 2016 - 2027)9
Figure North America Enzyme Replacement Therapy Revenue (M USD) and Growth Rate ( 2016 - 2027)10
Figure Europe Enzyme Replacement Therapy Revenue (M USD) and Growth Rate ( 2016 - 2027)11
Figure Asia - Pacific Enzyme Replacement Therapy Revenue (M USD) and Growth Rate ( 2016 - 2027)12
Figure South America Enzyme Replacement Therapy Revenue (M USD) and Growth Rate ( 2016 - 2027)13
Figure Middle East and Africa Enzyme Replacement Therapy Revenue (M USD) and Growth Rate ( 2016 - 2027)14
Figure Global Enzyme Replacement Therapy Revenue (M USD) Status and Outlook ( 2016 - 2027)15
Figure Global Enzyme Replacement Therapy Sales (K Unit) Status and Outlook ( 2016 - 2027)16
Table Global Enzyme Replacement Therapy Sales (K Unit) of Key Manufacturers ( 2020 - 2021)17
Table Global Enzyme Replacement Therapy Sales Market Share by Manufacturers ( 2020 - 2021)17
Figure 2020 Enzyme Replacement Therapy Sales Market Share by Manufacturers18
Figure 2021 Enzyme Replacement Therapy Sales Market Share by Manufacturers19
Table Global Enzyme Replacement Therapy Revenue (M USD) by Manufacturers ( 2020 - 2021)19
Table Global Enzyme Replacement Therapy Revenue Share by Manufacturers ( 2020 - 2021)20
Figure 2020 Global Enzyme Replacement Therapy Revenue Share by Manufacturers21
Figure 2021 Global Enzyme Replacement Therapy Revenue Share by Manufacturers22
Table Global Market Enzyme Replacement Therapy Average Price (USD/Unit) of Key Manufacturers ( 2020 - 2021)22
Figure Global Market Enzyme Replacement Therapy Average Price (USD/Unit) of Key Manufacturers in 202023
Table Manufacturers Enzyme Replacement Therapy Headquarters and Established Date23
Table Manufacturers Enzyme Replacement Therapy Product Type24
Figure 2020 Enzyme Replacement Therapy Revenue Market Share by Manufacturers25
Figure 2020 Enzyme Replacement Therapy Revenue Market Share of Top 3 Manufacturers26
Figure 2020 Enzyme Replacement Therapy Revenue Market Share of Top 5 Manufacturers27
Table Mergers & Acquisitions, Expansion27
Table Global Enzyme Replacement Therapy Sales (K Unit) by Regions ( 2016 - 2021)30
Table Global Enzyme Replacement Therapy Sales Market Share by Regions ( 2016 - 2021)30
Figure Global Enzyme Replacement Therapy Sales Market Share by Regions ( 2016 - 2021)31
Figure 2020 Global Enzyme Replacement Therapy Sales Market Share by Regions32
Table Global Enzyme Replacement Therapy Revenue (M USD) by Regions ( 2016 - 2021)32
Table Global Enzyme Replacement Therapy Revenue Market Share by Regions ( 2016 - 2021)33
Figure Global Enzyme Replacement Therapy Revenue Market Share by Regions ( 2016 - 2021)33
Figure 2020 Global Enzyme Replacement Therapy Revenue Market Share by Regions34
Figure Global Enzyme Replacement Therapy Sales (K Unit) and Growth Rate ( 2016 - 2021)35
Table Global Enzyme Replacement Therapy Sales (K Unit), Revenue (M USD), Price (USD/Unit) and Gross Margin ( 2016 - 2021)35
Figure North America Enzyme Replacement Therapy Sales (K Unit) and Growth Rate ( 2016 - 2021)36
Table North America Enzyme Replacement Therapy Sales (K Unit), Revenue (M USD), Price (USD/Unit) and Gross Margin ( 2016 - 2021)36
Figure Europe Enzyme Replacement Therapy Sales (K Unit) and Growth Rate ( 2016 - 2021)37
Table Europe Enzyme Replacement Therapy Sales (K Unit), Revenue (M USD), Price (USD/Unit) and Gross Margin ( 2016 - 2021)38
Figure Asia - Pacific Enzyme Replacement Therapy Sales (K Unit) and Growth Rate ( 2016 - 2021)39
Table Asia - Pacific Enzyme Replacement Therapy Sales (K Unit), Revenue (M USD), Price (USD/Unit) and Gross Margin ( 2016 - 2021)39
Figure South America Enzyme Replacement Therapy Sales (K Unit) and Growth Rate ( 2016 - 2021)40
Table South America Enzyme Replacement Therapy Sales (K Unit), Revenue (M USD), Price (USD/Unit) and Gross Margin ( 2016 - 2021)41
Figure Middle East & Africa Enzyme Replacement Therapy Sales (K Unit) and Growth Rate ( 2016 - 2021)42
Table Middle East & Africa Enzyme Replacement Therapy Sales (K Unit), Revenue (M USD), Price (USD/Unit) and Gross Margin ( 2016 - 2021)42
Table Global Enzyme Replacement Therapy Sales (K Unit) by Types ( 2016 - 2021)44
Table Global Enzyme Replacement Therapy Sales Market Share by Types ( 2016 - 2021)44
Figure Sales Market Share of Enzyme Replacement Therapy by Types ( 2016 - 2021)45
Figure 2020 Sales Market Share of Enzyme Replacement Therapy by Types45
Table Global Enzyme Replacement Therapy Revenue (M USD) by Types ( 2016 - 2021)46
Table Global Enzyme Replacement Therapy Revenue Share by Types ( 2016 - 2021)46
Figure Revenue Share of Enzyme Replacement Therapy by Types ( 2016 - 2021)46
Figure 2020 Revenue Market Share of Enzyme Replacement Therapy by Types47
Table Global Enzyme Replacement Therapy Price (USD/Unit) by Types ( 2016 - 2021)47
Figure Global Enzyme Replacement Therapy Sales Growth Rate by Types ( 2016 - 2021)48
Table Global Enzyme Replacement Therapy Revenue (M USD) by Applications ( 2016 - 2021)49
Table Global Enzyme Replacement Therapy Revenue Market Share by Applications ( 2016 - 2021)49
Figure Global Enzyme Replacement Therapy Revenue Market Share by Applications ( 2016 - 2021)50
Figure Global Enzyme Replacement Therapy Revenue Market Share by Applications in 202051
Figure Global Enzyme Replacement Therapy Revenue Growth Rate by Applications ( 2016 - 2021)52
Table Sanofi Company Profile53
Table Enzyme Replacement Therapy Product Introduction of Sanofi54
Table Enzyme Replacement Therapy Sales (K Unit), Price (USD/Unit), Cost (USD/Unit), Gross Profit (USD/Unit), Revenue (M USD) and Gross Margin of Sanofi 2020 - 202155
Table Shire Company Profile55
Table Enzyme Replacement Therapy Product Introduction of Shire56
Table Enzyme Replacement Therapy Sales (K Unit), Price (USD/Unit), Cost (USD/Unit), Gross Profit (USD/Unit), Revenue (M USD) and Gross Margin of Shire 2020 - 202157
Table BioMarin Company Profile58
Table Enzyme Replacement Therapy Product Introduction of BioMarin59
Table Enzyme Replacement Therapy Sales (K Unit), Price (USD/Unit), Cost (USD/Unit), Gross Profit (USD/Unit), Revenue (M USD) and Gross Margin of BioMarin 2020 - 202160
Table AbbVie Company Profile61
Table Enzyme Replacement Therapy Product Introduction of AbbVie62
Table Enzyme Replacement Therapy Sales (K Unit), Price (USD/Unit), Cost (USD/Unit), Gross Profit (USD/Unit), Revenue (M USD) and Gross Margin of AbbVie 2020 - 202163
Table Alexion Company Profile63
Table Enzyme Replacement Therapy Product Introduction of Alexion64
Table Enzyme Replacement Therapy Sales (K Unit), Price (USD/Unit), Cost (USD/Unit), Gross Profit (USD/Unit), Revenue (M USD) and Gross Margin of Alexion 2020 - 202165
Table Allergan Company Profile65
Table Enzyme Replacement Therapy Product Introduction of Allergan66
Table Enzyme Replacement Therapy Sales (K Unit), Price (USD/Unit), Cost (USD/Unit), Gross Profit (USD/Unit), Revenue (M USD) and Gross Margin of Allergan 2020 - 202167
Table Horizon Pharma Company Profile67
Table Enzyme Replacement Therapy Product Introduction of Horizon Pharma68
Table Enzyme Replacement Therapy Sales (K Unit), Price (USD/Unit), Cost (USD/Unit), Gross Profit (USD/Unit), Revenue (M USD) and Gross Margin of Horizon Pharma 2020 - 202169
Table Johnson & Johnson Company Profile69
Table Enzyme Replacement Therapy Product Introduction of Johnson & Johnson71
Table Enzyme Replacement Therapy Sales (K Unit), Price (USD/Unit), Cost (USD/Unit), Gross Profit (USD/Unit), Revenue (M USD) and Gross Margin of Johnson & Johnson 2020 - 202172
Table Actelion Company Profile72
Table Enzyme Replacement Therapy Product Introduction of Actelion73
Table Enzyme Replacement Therapy Sales (K Unit), Price (USD/Unit), Cost (USD/Unit), Gross Profit (USD/Unit), Revenue (M USD) and Gross Margin of Actelion 2020 - 202173
Table Recordati Rare Diseases Company Profile74
Table Enzyme Replacement Therapy Product Introduction of Recordati Rare Diseases75
Table Enzyme Replacement Therapy Sales (K Unit), Price (USD/Unit), Cost (USD/Unit), Gross Profit (USD/Unit), Revenue (M USD) and Gross Margin of Recordati Rare Diseases 2020 - 202176
Table Pfizer Company Profile76
Table Enzyme Replacement Therapy Product Introduction of Pfizer77
Table Enzyme Replacement Therapy Sales (K Unit), Price (USD/Unit), Cost (USD/Unit), Gross Profit (USD/Unit), Revenue (M USD) and Gross Margin of Pfizer 2020 - 202178
Table Digestive Care Company Profile78
Table Enzyme Replacement Therapy Product Introduction of Digestive Care79
Table Enzyme Replacement Therapy Sales (K Unit), Price (USD/Unit), Cost (USD/Unit), Gross Profit (USD/Unit), Revenue (M USD) and Gross Margin of Digestive Care 2020 - 202179
Table Leadiant Biosciences Company Profile80
Table Enzyme Replacement Therapy Product Introduction of Leadiant Biosciences81
Table Enzyme Replacement Therapy Sales (K Unit), Price (USD/Unit), Cost (USD/Unit), Gross Profit (USD/Unit), Revenue (M USD) and Gross Margin of Leadiant Biosciences 2020 - 202182
Figure Typical Phases from Research to Market for a Drug Candidate84
Table Out - of - pocket Preclinical and Clinical Period Cost per Investigational Biopharmaceutical Compound85
Table Capitalized Preclinical and Clinical Period costs per Investigational Biopharmaceutical Compound86
Figure Manufacturing Cost Structure of Enzyme Replacement Therapy86
Figure USA Labor Cost Analysis 2015 - 202187
Figure Cost of Employing a Factory Worker88
Figure Europe Labor Cost Analysis 2015 - 202189
Figure Germany Labor Cost Analysis 2015 - 202189
Figure UK Labor Cost Analysis 2015 - 202190
Figure France Labor Cost Analysis 2015 - 202190
Figure Italy Labor Cost Analysis 2015 - 202191
Figure Monthly Minimum Wages in Asia 201691
Figure China Labor Costs 2015 - 202192
Figure Japan Average Monthly Wages 2015 - 202192
Figure Global Electricity Prices by Select Countries in 2020 (in U.S. Dollars per Kilowatt Hour)93
Table Average Price of Electricity to Ultimate Customers 2007 - 202194
Figure Electricity Prices for Househol
